Store at room temperature away from light-weight and dampness. Unique makes of this medication have various storage requirements. Examine the item package for Guidance regarding how to keep your brand name, or inquire your pharmacist. Continue to keep all prescription drugs from kids and Animals.
Mechanism of Motion Codeine is undoubtedly an opioid agonist comparatively selective for that mu-opioid receptor, but having a A great deal weaker affinity than morphine.
e., several copies with the gene for cytochrome P450 isoenzyme 2D6 or high morphine concentrations). Kids with snooze apnea may be specifically delicate to the respiratory depressant results of codeine. As a result of hazard of life-threatening respiratory melancholy and Demise:
Acetaminophen and codeine phosphate tablets are contraindicated for postoperative administration in pediatric patients youthful than 18 yrs of age adhering to tonsillectomy and/or adenoidectomy (see CONTRAINDICATIONS).
Though serious, lifestyle-threatening, or fatal respiratory depression can come about Anytime throughout the usage of acetaminophen and codeine phosphate tablets, the danger is finest throughout the initiation of therapy or pursuing a dosage boost.
Wean the affected individual off of your opioid to permit adrenal operate to Get well and continue on corticosteroid procedure right until adrenal operate recovers. Other opioids may very well be attempted as some situations described usage of another opioid devoid of recurrence of adrenal insufficiency. The knowledge obtainable would not establish any unique opioids as staying a lot more prone to be associated with adrenal insufficiency.
Focus on the availability of naloxone to the crisis remedy of opioid overdose While using the individual and caregiver and evaluate the possible will need for access to naloxone, both equally when initiating and renewing treatment method with acetaminophen and codeine phosphate tablets (see WARNINGS, Everyday living-Threatening Respiratory Depression; Safeguards, Information for Clients/Caregivers).
Extensive-time period use here of opioid medication may possibly have an effect on fertility (capacity to have young children) in Males or Gals. It's not necessarily recognized whether opioid consequences on fertility are lasting.
Due to related pharmacological Attributes, it's acceptable to expect equivalent possibility Using the concomitant utilization of other CNS depressant prescription drugs with opioid analgesics (see PRECAUTIONS, Drug Interactions).
Shop acetaminophen and codeine phosphate tablets securely, away from sight and access of youngsters, As well as in more info a area not obtainable by Other people, which include guests to the home.
People should be instructed to not discontinue this drug read more devoid of initially talking about a tapering strategy with their check here Health care company.
aan erection that will not go away (priapism). When more info you have an erection that lasts much more than 4 hrs, get medical support at once. If It isn't addressed without delay, priapism can completely destruction your penis. unexpected eyesight loss in a single or each eyes. Sudden vision loss in one or each eyes is usually a signal of a significant eye dilemma identified as non-arteritic anterior ischemic optic neuropathy (NAION).
Opioid analgesics, which includes acetaminophen and codeine phosphate tablets, can lengthen labor through actions which temporarily decrease the toughness, duration, and frequency of uterine contractions. On the other hand, this effect just isn't reliable and may be offset by a heightened amount of cervical dilation, which has a tendency to shorten labor. Check neonates subjected to opioid analgesics during labor for indications of excess sedation and respiratory depression.
Accidental ingestion of acetaminophen and codeine phosphate tablets, Particularly by kids, can result in respiratory depression and Dying as a consequence of an overdose of codeine.